郭新东 教授

E-mail: xdguo@buct.edu.cn

办公室：有机楼214

教育研究经历

2013.11-至今           北京化工大学，教授

2011.7-2013.9          美国佐治亚理工学院，博士后

2010.7-2013.11         华南理工大学，讲师

2007.11-2008.11       新加坡生物工程与纳米科技研究院，联合培养

2010.7                     华南理工大学，化学工程，工学博士

2004.7                     南京理工大学，高分子材料与工程，工学学士

研究领域

致力于开展高分子材料与工程、化学工程、纳微技术、生物医学工程等多学交叉领域最具前沿和挑战性的研究。针对打针注射疼痛、产生大量医疗垃圾等问题，通过综合运用多学科的理论和方法，设计与开发新型无痛高分子微针给药系统。具体研究方向如下：

1.         高分子微针的设计与开发。

2.         高分子微针载体材料的分子设计与合成。

3.         多尺度模拟研究药物传输系统中的结构性能关系。

研究成果及获奖情况

研究成果在Biomaterials, Macromolecules, J. Controlled Reslease, Soft Matter, AIChE Journal, Nature Chemistry, International Journal of Pharmaceutics, Biomacromolecules, Langmuir等重要学术刊物上发表学术论文30余篇，申请中国发明专利6项，美国发明专利2项。现主持国家自然科学基金、教育部博士点基金、广东省自然科学基金团队项目（5位核心成员之一）等多项基金。

2012     全国优秀博士学位论文提名奖。

2011     广东省优秀博士学位论文。

代表性论文

1.        Xin Dong Guo, N Wiradharma, SQ Liu, LJ Zhang, M Khan, Y Qian, Y-Y Yang, Oligomerized alpha-helical KALA peptides with pendant arms bearing cell-adhesion, DNA-binding and endosome-buffering domains as efficient gene transfection vectors, Biomaterials, 2012, 33(26): 6284-6291.

2.        Xin Dong Guo, Y Qian, CY Zhang, SY Nie, LJ Zhang, Can drug molecules diffuse into the core of micelles? Soft Matter, 2012, 8(39): 9989-9995. (封面文章)

3.        Xin Dong Guo, JPK Tan, SH Kim, LJ Zhang, Y Zhang, JL Hedrick, YY Yang, Y Qian, Computational Studies on Self-Assembled Paclitaxel Structures: Templates for Hierarchical Block Copolymer Assemblies and Sustained Drug Release, Biomaterials, 2009, 30(33): 6556-6563.

4.        Xin Dong Guo, F Tandiono, N Wiradharma, CG Tan, D Khor, M Khan, Y Qian, YY Yang, Cationic Micelles Self-Assembled from Cholesterol-Conjugated Oligopeptides as An Efficient Gene Delivery Vector, Biomaterials, 2008, 29: 4838-4846.

5.        Xin Dong Guo, LJ Zhang, Y Chen, Y Qian, Core/shell pH-sensitive micelles self-assembled from cholesterol conjugated oligopeptides for anticancer drug delivery, AIChE Journal, 2010, 56(7): 1922-1931. (封面文章)

6.        Xin Dong Guo, LJ Zhang, ZM Wu, Y Qian, Dissipative particle dynamics studies on microstructure of pH-sensitive micelles for sustained drug delivery, Macromolecules, 2010, 43(18): 7839-7844.

7.        Xin Dong Guo, MR Prausnitz, Microelectronic control of drug delivery, Expert Review of Medical Devices, 2012, 9(4): 323-326.

8.        Xin Dong Guo, LJ Zhang, Y Qian, A systematic multiscale method for studying the structure-performance relationship of drug delivery systems, Industrial & Engineering Chemistry Research, 2012, 51(12): 4719-4730.

9.        Xin Dong Guo, LJ Zhang, ZM Wu, Y Qian, Studies on pH-sensitive micellar structures for sustained drug delivery: Experiments and computer simulations, Journal of Controlled Release, 2011, 152(1 Supplement 1): e26-e28.

10.    Xin Dong Guo, LJ Zhang, Y Qian, J Zhou, Effect of composition on the formation of poly (_DL-lactide) microspheres for drug delivery systems, Chemical Engineering Journal, 2007, 131: 195-201.